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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSF1
All Species:
19.39
Human Site:
S435
Identified Species:
42.67
UniProt:
Q00613
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00613
NP_005517.1
529
57260
S435
S
L
P
D
L
D
S
S
L
A
S
I
Q
E
L
Chimpanzee
Pan troglodytes
XP_001161258
492
53052
G399
I
G
P
L
D
V
L
G
P
S
L
Q
G
R
E
Rhesus Macaque
Macaca mulatta
XP_001108944
517
58258
V424
E
T
T
K
N
N
V
V
Q
P
V
S
E
E
G
Dog
Lupus familis
XP_849103
517
56003
S423
S
L
P
D
L
D
S
S
L
A
S
I
Q
E
L
Cat
Felis silvestris
Mouse
Mus musculus
P38532
525
57205
S431
S
L
P
D
L
D
S
S
L
A
S
I
Q
E
L
Rat
Rattus norvegicus
NP_077369
525
57091
S431
S
L
P
D
L
D
S
S
L
A
S
I
Q
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512133
411
44232
L318
K
C
L
S
V
A
C
L
D
N
P
A
G
Q
N
Chicken
Gallus gallus
P38529
491
53580
S397
N
L
P
D
L
D
S
S
L
A
S
I
Q
D
L
Frog
Xenopus laevis
P41154
451
49454
E358
S
L
S
R
Q
M
S
E
V
S
R
L
F
P
T
Zebra Danio
Brachydanio rerio
NP_571675
538
59923
D441
D
S
L
A
S
I
Q
D
L
L
S
P
D
P
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22813
691
76915
S538
L
L
D
A
N
Q
A
S
T
S
K
A
A
A
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
38
37.8
89.4
N.A.
89.4
89.4
N.A.
58.4
74.4
55
58.5
N.A.
29.5
N.A.
N.A.
N.A.
Protein Similarity:
100
51.9
55.5
92.4
N.A.
93.1
93.3
N.A.
65.9
83.9
64.8
72.1
N.A.
45.1
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
6.6
100
N.A.
100
100
N.A.
0
86.6
20
13.3
N.A.
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
13.3
20
100
N.A.
100
100
N.A.
13.3
100
40
20
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
19
0
10
10
0
0
46
0
19
10
10
0
% A
% Cys:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
46
10
46
0
10
10
0
0
0
10
10
0
% D
% Glu:
10
0
0
0
0
0
0
10
0
0
0
0
10
46
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
10
0
0
0
0
0
10
0
0
0
0
19
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
10
0
0
0
0
0
46
0
0
0
% I
% Lys:
10
0
0
10
0
0
0
0
0
0
10
0
0
0
10
% K
% Leu:
10
64
19
10
46
0
10
10
55
10
10
10
0
0
46
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
19
10
0
0
0
10
0
0
0
0
10
% N
% Pro:
0
0
55
0
0
0
0
0
10
10
10
10
0
19
0
% P
% Gln:
0
0
0
0
10
10
10
0
10
0
0
10
46
10
0
% Q
% Arg:
0
0
0
10
0
0
0
0
0
0
10
0
0
10
0
% R
% Ser:
46
10
10
10
10
0
55
55
0
28
55
10
0
0
0
% S
% Thr:
0
10
10
0
0
0
0
0
10
0
0
0
0
0
10
% T
% Val:
0
0
0
0
10
10
10
10
10
0
10
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _